Exosomes Production

What Are Exosomes?

Exosomes are small membrane extracellular vesicles (EVs) that consist of a heterogeneous population of small EVs (30-100nm in diameter) and micro vesicles (100-1000nm in diameter).  Exosomes are secreted by a multitude of cell types that play key roles in cell-to-cell communication, including Mesenchymal Stem Cells (mSCs). Exosomes are found in most body fluids and have been shown to play key roles in processes such as coagulation, intercellular signaling, immune responses, and cellular waste management because they  contain bioactive molecules, including proteins, RNAs and microRNAs.

Broad applications of exosomes have included delivery of biologics payloads to cells such as DNA, mRNAs, peptides and proteins, therapeutics treatments for Covid-19, cancer, rare diseases, and in the cosmeceutical applications.

Exosomes Production

Exosomes Production And Purification

Exosomes are a novel form of biotherapeutics, but their production and purification are similar to conventional biologics manufacturing in terms of cell culture and bioreactor (upstream) and purification (downstream) development.

Addressing Challenges With Production and Manufacturing

From a manufacturing perspective, the challenge resides not only in the manufacturing but also in the characterization of the biologic. Most developers of these innovative technologies are in preclinical and early clinical stages working towards the demonstration of the efficacy and the potential of exosomes based therapeutics and cosmeceutics. 

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